ATTRACT-1 Phase III Trial Of ASA404 Halted Following Interim Analysis
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Antisoma plc (LSE: ASM; USOTC: ATSMY) announces that the aforethought meantime psychoanalysis of information from the ATTRACT-1 form III tribulation of ASA404 in antecedently untreated non-small cadre lung cancer (NSCLC) has shown that prolongation of the test would be otiose, as thither is niggling or no vista of demonstrating a selection welfare with ASA404 in this background. The ATTRACT-1 tribulation testament thence be halted.
No new or unexpected sober untoward effects of ASA404 deliver been identified by the test’s Data Monitoring Committee.
Glyn Edwards, CEO of Antisoma, aforesaid: “We are frustrated by the resultant of the ATTRACT-1 discipline, particularly presumption the rattling supporting stage II information reported in the like scope. We had hoped that this test would demonstrate that use of ASA404 could meliorate discussion for patients with freshly diagnosed lung cancer. We are now focussed on delivering stage III results for our otc late-stage ware, AS1413.”
Antisoma had unaudited cash and short-run investments of GBP 45.1 billion at the end of February 2010.
ATTRACT-1 was a polar work of ASA404 in antecedently untreated, forward-looking NSCLC. Patients were randomized 1:1 to welcome either ASA404 positive chemotherapy (carboplatin/paclitaxel) or a placebo summation chemotherapy (carboplatin/paclitaxel) as a restraint.
ASA404 (vadimezan, erstwhile known as DMXAA and AS1404) is a small-molecule Tumour-Vascular Disrupting Agent (Tumour-VDA) which targets the lineage vessels that nutrify tumours. The dose wasdiscovered by Professors Bruce Baguley and William Denny and their teams at the Auckland Cancer Society Research Centre, University of Auckland, New Zealand. It was in-licensed by Antisoma from Cancer Research Ventures Limited (now Cancer Research Technology), the maturation and commercialization accompany of the Cancer Research Campaign (now Cancer Research UK), in 2001. Worldwide rights to the dose were accredited to Novartis AG in April 2007.
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