Research links Bayer’s Yasmin with higher risk of blood clots
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The guard of Bayer’s unwritten prophylactic Yasmin has been called into dubiousness on the cover of new inquiry, promulgated in the British Checkup Journal , which suggests the tab’s drospirenone ingredient may represent a higher hazard of ancestry clots than levonorgestrel-based rivals.
In one discipline, researchers victimised the UK Oecumenical Recitation Enquiry Database to expression at women cured 15-44 years who had no major jeopardy factors for venous thromboembolism (VTE) and were initiated on an viva antifertility containing estrogen in compounding with either drospirenone or levonorgestrel ‘tween May 2002 and September 2009.
The results of the case-controlled psychoanalysis indicate that those pickings the drospirenone preventive were leash multiplication more probable to break non-fatal bloodline clots than those on levonorgestrel-based ones, adding to maturation tell that the combined viva prophylactic containing drospirenone carries a higher endangerment VTE, the researchers tone.
Writing in the BMJ , they birdsong for a systemic reappraisal on the matter, and intimate that, in the lag, “as no open manifest exists to prove that the use of the drospirenone tab confers benefits supra those of over-the-counter unwritten contraceptives in preventing gestation, treating acne, alleviating premenstrual syndrome, or avoiding burthen addition, prescribing lour danger levonorgestrel preparations as the outset demarcation selection in women wish to yield an unwritten preventative would appear prudent”.
The findings were echoed by a offprint survey besides promulgated in the BMJ based on US claims information, which showed the adventure of non-fatal VTE among users of preventive pills containing drospirenone to be double as gamy as levonorgestrel.
In demurrer…
But Bayer was prompt to hold the rubber visibility of its Yasmin dealership. It argues that the discipline methodology reported in these two publications “read substantial flaws and the databases victimised supply less true conclusions than are uncommitted from existent scientific tell”.
“Clinical information from a menstruum of more than 15 years and up to 10 years of post-marketing safe bailiwick results reenforcement Bayer’s judgment that its drospirenone-containing [contraceptives] are good and good when victimised as indicated and that the adventure of VTE is interchangeable to any early low-dose oestrogen [anovulant] studied, disregarding of the progestin,” aforesaid Ilka Schellschmidt, Drumhead Planetary Checkup Affairs Women’s Healthcare at the party.
venous thromboembolism VTE drospirenone origin clots levonorgestrel BMJ Bayer
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